Fig. 1

Patient-specific tissue engineering scaffolds require robust quality assurance metrics. (A) General workflow for design and manufacture of custom, porous bone scaffolds. Solid scaffold geometry is generated from anatomic geometry of defect site. (B) Custom design and manufacture of 2 cm porcine zygomatic porous scaffold to treat the shown defect. Solid scaffold is assigned a custom porous pattern (blue). The design is 3D printed and scanned. CBCT scan (green) of manufactured scaffold provides its digital representation. Subsequent QA involves 3D correlation between manufactured scaffold and design intent to produce quality readout